Tox +

Toxicology Panels


Patients Choice Laboratories™ (PCL) in Indianapolis, IN provides confirmatory drug testing with Liquid Chromatography-Mass Spectrometry (LC-MS), the gold standard in clinical toxicology drug testing. LC-MS provides highly sensitive and precise testing to confirm positive results from toxicology drug screening with immunoassays or in-clinic dipstick screens. This service will help you provide unbiased, third party support for your patients to ensure they are benefiting as much as possible from their medication regimens.

Confirmatory drug testing with LC-MS provides additional information to supplement screening results. Screening tests detect drugs by class; however, it is unable to determine the specific drug that is present in the sample. For example, a sample may be positive on a screening test for opiates, but the screen is incapable of defining the specific drug present in the specimen. LC-MS testing provides confirmation of positive samples and additionally identifies the specific drug(s) present.

PCL’s toxicology report is provided to you in a format that is easy to read and color-coded for quick interpretation. The turn-around time for confirmatory testing is 24 to 72 hours from sample receipt. Your patient’s results will be delivered to you in a HIPAA-compliant online portal.

Tests may be ordered by drug class or as a comprehensive panel. All testing has been extensively validated in-house by experienced clinical scientists. PCL is CLIA and COLA accredited and registered with the College of American Pathologists (CAP) for accreditation, which will be completed by 2016.

Ascent Software

One lab. One quality standard.

Today’s analytical production laboratory is often characterized by two things:

  • a vibrant and diverse team of individuals,
  • running on a limited (or even singular) platform of mass spectrometry instrumentation with a dedicated data system.

In reviewing the laboratory landscape, our guiding principles were: “what are the strengths of such an approach, and what are the opportunities for improvement?”

Automated rules for more consistent results.

A broad base of users creates a dynamic environment for problem solving and enriches the working culture.  However, when it comes to producing defensible results in a highly regulated climate, the overall system can be improved by taking advantage of software automation.  ASCENT’s customizable quality rule system takes the perspective of your most sophisticated and experienced operators and makes it available to each and every employee.  All data are consistently reviewed for quality in exactly the same manner – the manner which has been customized to meet your laboratory’s specific quality policies and SOP.

Vendor-neutral capability so you can choose the instrument that’s the best fit.

Instrumentation inventory from a single vendor can provide commonality advantages in ease of operation and maintenance.  However, when it comes to versatility and flexibility, there can be real benefits to utilizing instrumentation from multiple vendors, e.g. instruments with different ion source designs, which may work better for certain classes of compounds.  What has prevented some labs from taking advantage of these competitive capabilities has been the instrument data system – learning a different data system for each different instrument presents a barrier to productivity.  ASCENT’s vendor-neutral capability means that you are now free to choose the brand and model of instrument that is scientifically and economically the best choice for your lab. All of the processing, reviewing and reporting functions will be identical across your entire laboratory, building upon the quality system described above.

ASCENT’s peak processing and other core elements means that instruments of the same – or in many cases, merely similar – manufacture can utilize a single method. Using a single, robust method across multiple systems dramatically reduces the amount of method modification that has been necessary in the past to address operational differences or instrument fatigue. Imagine maintaining all of your analytical methods and managing all of your analytical data with a single, streamlined system.

PCL provides quality, accurate confirmatory testing for a number of physicians and other health care professionals, including:
  • Private doctor’s offices and clinics
  • Pain management clinics
  • Mental health clinics
  • Cardiac clinics
  • Substance abuse clinics and organizations

Our laboratory is continuously validating additional drugs to expand our toxicology test menu to offer you the most comprehensive drug testing to best support your patients. Currently, the following drugs are validated and available for testing:


Drug Classes

Drugs and Metabolites Detected

Amphetamines Amphetamines, Methamphetamine, MDEA, MDMA
Barbiturates Butalbital, Phenobarbital
Benzodiazepines Alprazolam, Hydroxyalprazolam, Clonazepam, 7-Aminoclonazipam, Diazepam, Nordiazepam, Lorazepam, Oxazepam, Temazepam
Buprenorphine Buprenorphine, Norbuprenorphine
Cannabinoids THC-COOH
Dextromethorphan Dextromethorphan, Dextrorphan
Ethyl Glucuronide Ethyl Glucuronide (EtG), Ethyl Sulfate (EtS)
Illicits 6-MAM, Cocaine, PCP
Ketamine Ketamine, Norketamine
Muscle Relaxers Carisoprodol, Meprobamate, Cyclobenzaprine
Opiates Codeine, Hydrocodone, Hydromorphone, Morphine, Norhydrocodone, Noroxycodone, Oxycodone, Oxymorphone
Sedatives Zolpidem, Zolpidem Phenyl-4-Carboxylic Acid
SSRI/Antidepressants Hydroxybuproprion, Venlafaxine, Citalopram, Doxepin, Fluoxetine, Paroxetine, Sertraline
Stimulants Methylphenidate, Ritalinic Acid, Phentermine
Synthetic Opioids Fentanyl, Norfentanyl, Meperidine, Normeperidine, Methadone, EDDP, Tapentadol, Tramadol
Synthetics Mitragynine, MDPV, JWH-018 Pentanoic Acid, UR-144 5-Hydroxypentyl
Tricyclic Antidepressants Amitriptyline, Desipramine, Imipramine, Nortriptyline
Other Naloxone, Gabapentin, Pregabalin, Naltrexone, Propoxyphone

For more information about ordering confirmatory testing, please contact a PCL Client Services Representative at 

References:  J Addict Dis.2010 Oct;29(4):436-48.  |  Center for Substance Abuse Treatment. Improving Treatment for Drug-Exposed Infants. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 1993. (Treatment Improvement Protocol (TIP) Series, No. 5.) Appendix C – Urine toxicology Guidelines.Available from: