Pharmacogenetics Testing

PGx+

Patient’s Choice Laboratories™ (PCL) is proud to offer the following Pharmacogenetic (PGx) tests to help you to better serve your patients. Pharmacogenetic testing provided by PCL will allow you to deliver personalized medicine to your patients that is custom-tailored to their specific needs and conditions such as pain management, mental health, and cardiovascular risk. These tests have been extensively validated in-house by highly trained scientists under strict conditions that satisfy CLIA and CAP requirements.

Testing genes involved in metabolism of pharmaceuticals can provide important genetic information to help you identify the ideal drug for your patients, offering the opportunity to maximize the therapeutic effect while reducing adverse drug reactions (ADRs).

Results will be reported in standard nomenclature such as “Poor Metabolizer”, “Intermediate Metabolizer”, “Normal Metabolizer”, and “Rapid Metabolizer”, with specific recommendations based on clinical research for the medications your patients are taking that can be listed on the requisition form.

 

Poor Metabolizer (PM): Presence of mutations, usually on both chromosomes or in multiple locations on the gene, which significantly decrease or completely inhibit expression of the mutated gene. This generally results in a decreased dosage recommendation or change in medication to something more easily metabolized by the patient.

Rapid Metabolizer (RM): Presence of mutations, usually on both chromosomes or in multiple locations on a gene, which significantly increase expression of the mutated gene. This generally results in an increased dosage recommendation.

Intermediate Metabolizer (IM): Presence of mutations on only one chromosome, or multiple mutations only partially effecting expression of the mutated gene.

Wild Metabolizer (NM): No detected mutations (wild type).

Pharmacogenetic Tests Available from Patients Choice Laboratories

Comprehensive Solution

The Comprehensive Test includes all of the genes PCL tests, which apply to multiple conditions including pain management, heart medications, general drug metabolism, mental health treatments, and cardiovascular risk factors.


ABCB1, ADRA2A, AGTR1, ALDH2, ANKK1, APOB, APOE, ATM, BDNF, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP4F2, DPYD, DRD2, F2, F5, FUT2, G6PD, GSTP1, HFE, HLA-B, HTR2A, HTR2C, IFNL3, KIF6, LDLR, MTHFR, NAT2, NBPF3, OPRM1, SLCO1B1, SLC6A4, SCN2A, TPMT, UGT2B7, UGT2B15, VKORC1, XRCC1

Cardiovascular Solution

The Cardiovascular Test includes genes involved in metabolism of pharmaceuticals prescribed to cardiac patients such as Warfarin (Coumadin), Clopidogrel (Plavix), and beta blockers as well as a screen for mutations that are risk factors for thrombosis. 


ABCB1, ADRA2A, AGTR1, APOB, APOE, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP4F2, F2, F5, KIF6, LDLR, MTHFR, NATZ, NBPF3, SLCO1B, VKORC1

Mental Health Solution

The Mental Health Test includes a complete analysis for genes associated with medications used in the treatment of psychiatric conditions, including depression.


ADRA2A, ALDH2, ANKK1, BDNF, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, DRD2, ERCC1, FUT2, HTR2A, HTR2C, SCN2A, SLC6A4

Oncology Solution

The Oncology Test can help ensure your treatment plan along with its response and toxicity to chemotherapy. Pharmacogenetic testing for these genes can help physicians reduce the time it takes to find the right medication with the least amount of negative side effects.


ABCB1, CYP2CP, CYP2C19, CYP2D6, CYP3A4, DPYD, G6PD, GSTP1, MTHFR, SLCO1B1, TPMT, XRCC1

Optimal Solution

The Optimal Test includes genes that are important in the metabolism of many types of drugs. Knowing the genotype for these genes can provide physicians with information to personalize medication profiles by increasing the effectiveness and decreasing the negative side effects of medications.


ABCB1, AGTR1, ALDH2, ANKK1, APOE, BDNF, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, DRD2, F2, F5, FUT2, HTR2A, HTR2C, MTHFR, NBPF3, OPRM1, SLCO1B1, UGT2B7, G6PD, VKORC1, CYP4F2, NAT2, ATM, HFE, HLA-B, IFNL2, UGT2B15

Pain Solution

When a patient’s metabolism is reduced or eliminated due to mutations in the genes on the Pain Solution, narcotics will deliver insufficient pain relief and potentially become toxic. When metabolism is increased from other mutations, negative side effects such as decreased respiratory function, nausea, and excessive sedation.


COMT, CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, HLA-B, MTHFR, OPRM1, UGT2B7

Peri/Post Operative Solution

The Peri/Post Operative Test includes genes important for pain management. This helps ensure physicians prescribe the best medication for each individuals’ genetic makeup, that is more effective with less side effects. Selecting the correct medication can assist in preparation and recovery after surgery.


ADRA2A, APOE, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, F2, F5, FUT2, G6PD, HFE, MTHFR, OPRM1, UGT2B7