Pharmacogenetics Testing

PGx+

Patients Choice Laboratories™ (PCL) is proud to offer Pharmacogenetics (PGx+) testing to help you take control of your health. PGx+ testing provided by PCL delivers personalized options that are custom-tailored to your specific needs. These genetic tests have been extensively validated by highly trained scientists in our laboratory under strict conditions that satisfy state and federal clinical laboratory compliance requirements.

Many of the genes on PCL Pharmacogenetics tests play a large role in how your body breaks down medications. Changes in the nucleotide sequences of these genes, called mutations, can have a significant effect on how fast or slow your body metabolizes drugs; some mutations even cause a complete lack of drug metabolism!

Our PGx+ tests can provide genetic information to help you and your doctor decide the best medication you and your metabolism. Using this information in deciding your drug regimen can increase first prescription accuracy and improve the effectiveness of your medications while reducing negative side effects.

Pharmacogenetics testing is fast, easy, and accurate:

  • Your genotype doesn’t change, so the test only has to be performed once in your life.
  • PCL uses state-of-the-art testing methods with high levels of accuracy.
  • Sample collection is very simple, requiring just a few seconds with a buccal (cheek) swab.

Comprehensive Solution

The Comprehensive Test includes all of the genes PCL tests for, which apply to multiple conditions including pain management, heart medications, general drug metabolism, mental health treatments, and cardiovascular risk factors.


ABCB1, ADRA2A, AGTR1, ALDH2, ANKK1, APOB, APOE, ATM, BDNF, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP4F2, DPYD, DRD2, F2, F5, FUT2, G6PD, GSTP1, HFE, HLA-B, HTR2A, HTR2C, IFNL3, KIF6, LDLR, MTHFR, NAT2, NBPF3, OPRM1, SLCO1B1, SLC6A4, SCN2A, TPMT, UGT2B7, UGT2B15, VKORC1, XRCC1

Cardiovascular Solution

The Cardiovascular Test includes genes involved in metabolism of pharmaceuticals prescribed to cardiac patients such as Warfarin (Coumadin), Clopidogrel (Plavix), and beta blockers as well as a screen for mutations that are risk factors for thrombosis.


ABCB1, ADRA2A, AGTR1, APOB, APOE, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP4F2, F2, F5, KIF6, LDLR, MTHFR, NATZ, NBPF3, SLCO1B, VKORC1

Mental Health Solution

The Mental Health Test includes a complete analysis for genes associated with medications used in the treatment of psychiatric conditions, including depression.


ADRA2A, ALDH2, ANKK1, BDNF, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, DRD2, ERCC1, FUT2, HTR2A, HTR2C, SCN2A, SLC6A4

Oncology Solution

The Oncology Test can help ensure your treatment plan along with your response and toxicity to chemotherapy. Pharmacogenetic testing for these genes can help you and your doctor reduce the time it takes to find the right medication with the least amount of negative side effects.


ABCB1, CYP2CP, CYP2C19, CYP2D6, CYP3A4, DPYD, G6PD, GSTP1, MTHFR, SLCO1B1, TPMT, XRCC1

Optimal Solution

The Optimal Test includes genes that are important in the metabolism of many types of drugs. Knowing your genotype for these genes can provide you and your doctor with information to personalize your medication profile by increasing the effectiveness and decreasing the negative side effects of medications you take.


ABCB1, AGTR1, ALDH2, ANKK1, APOE, BDNF, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, DRD2, F2, F5, FUT2, HTR2A, HTR2C, MTHFR, NBPF3, OPRM1, SLCO1B1, UGT2B7, G6PD, VKORC1, CYP4F2, NAT2, ATM, HFE, HLA-B, IFNL2, UGT2B15

Pain Solution

When a patient’s metabolism is reduced or eliminated due to mutations in the genes on the Pain Test Solution, narcotics will deliver insufficient pain relief and potentially become toxic. When metabolism is increased from other mutations, negative side effects such as decreased respiratory function, nausea, and excessive sedation.


COMT, CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, HLA-B, MTHFR, OPRM1, UGT2B7

Peri/Post Operative Solution

The Peri/Post Operative Test includes genes important for pain management. This helps ensure you are prescribed the best medication for your genetic makeup that is more effective with less side effects. Selecting the correct medication can assist in preparation and recovery after surgery.


ABCB1, AGTR1, ALDH2, ANKK1, APOE, BDNF, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, DRD2, F2, F5, FUT2, HTR2A, HTR2C, MTHFR, NBPF3, OPRM1, SLCO1B1, UGT2B7, G6PD, VKORC1, CYP4F2, NAT2, ATM, HFE, HLA-B, IFNL2, UGT2B15